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Bile pigments, including bilirubin and biliverdin, contribute importantly to the defense against oxidative stress. Moreover, recent clinical studies suggest that mildly elevated serum bilirubin levels might protect from certain forms of cancer. Artificial bezoar (powdered bovine gallstones, also known as Niu Huang, or Calculus bovis) is used in traditional Chinese medicine for centuries for its antipyretic and anti-inflammatory properties. In the present experimental study, we investigated the effect of artificial bezoar on proliferation of human pancreatic cancer.